Induction of male-typical aggression by androgens but not by estrogens in adult female mice |
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| Authors: | N G Simon R E Whalen M P Tate |
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| Affiliation: | 1. Department of Psychology, Lehigh University, Bethlehem, Pennsylvania 18015, USA;2. Department of Psychology, University of California, Riverside, California 92521 USA |
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| Abstract: | Ovariectomized adult CF-1 female mice were implanted with silastic capsules containing either testosterone (T), dihydrotestosterone (DHT), methyltrienolone (R1881), estradiol (E2), diethylstilbestrol (DES), or oil vehicle and were tested for aggressive behavior. The androgenic treatments (T, DHT, R1881) were highly effective in promoting male-like aggression while the estrogens (DES, E2) were completely ineffective. Subsequent receptor-binding studies confirmed assumptions about the specificity of DES, DHT, and R1881 binding to estrogen and androgen receptors in mouse hypothalamus. |
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| Keywords: | To whom requests for reprints should be sent. |
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