Two new pyrazines from the parent roots of Aconitum carmichaelii |
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| Institution: | 1. State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, PR China;2. Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China;1. College of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, PR China;2. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China;3. Collaborative Innovation Center of Modern Biological Breeding, Xinxiang 453003, Henan Province, PR China;1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;2. National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing, 100700, China;3. Hunan University of Science and Engineering, Yongzhou, 425199, China;4. School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha, 410208, China;1. School of Chemical Science and Engineering, Yunnan University, Kunming, China;2. Faculty of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, China |
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| Abstract: | Two new pyrazines, aconicarpyrazine A (1) and aconicarpyrazine B (2), together with five known heterocyclic compounds: adenosine (3), uridine (4), hypoxanthine (5), nicotinamide (6), and uracil (7), were isolated from the parent roots of Aconitum carmichaelii. The structures of these alkaloids were elucidated by spectroscopic analysis, including 2D NMR techniques. This is the first report of pyrazines in a species of Aconitum. |
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