40～60岁饮酒史男性慢性萎缩性胃炎患病率和幽门螺杆菌感染率及肠道菌群分析

分析40～60岁饮酒史男性慢性萎缩性胃炎（CAG）患病率、幽门螺杆菌（H. pylori）感染率及肠道菌群，为该类患者的治疗提供参考。

采取整群抽样方法选取2020年2月至2022年2月于我院行胃镜检查的1 500例体检者，统计CAG患病率，根据CAG患病情况分为CAG组（n = 428）和无CAG组（n = 1 072），分析两组对象临床资料（性别、年龄、饮酒史等），观察其中40～60岁饮酒史男性患者CAG患病率、H. pylori感染情况及肠道菌群，并通过多因素Logistic回归分析CAG的相关影响因素。

CAG组患者性别、年龄、饮酒史、H. pylori感染情况与无CAG组对比差异均有统计学意义（均P＜0.05）。多因素Logistic回归分析显示，年龄40～60岁、男性、有饮酒史及H. pylori阳性均为影响CAG患病的独立危险因素（均P＜0.05）。40～60岁饮酒史男性CAG患病率为68.68%（296/431），其中伴有肠上皮化生者103例（34.80%），伴有活动性炎症者83例（28.04%），伴有不典型增生者45例（15.20%），H. pylori阳性率为63.51%（188/296）。伴有肠上皮化生、活动性炎症及不典型增生的CAG患者H. pylori阳性率均高于无上述情况者（均P＜0.05）。40～60岁饮酒史男性CAG患者肠道菌群数量与无CAG的体检者相比，差异均有统计学意义（均P＜0.05）。

40～60岁饮酒史男性CAG患病率和H. pylori阳性率较高，肠道菌群失衡更严重，其中伴有肠上皮化生、活动性炎症及不典型增生的CAG患者H. pylori阳性率更高。年龄40～60岁、男性、存在饮酒史及H. pylori阳性均为影响CAG患病的独立危险因素。

Prevalence rate of chronic atrophic gastritis, Helicobacter pylori infection and intestinal flora analysis in males aged 40 - 60 years with drinking history

ObjectiveTo analyze the prevalence rate of chronic atrophic gastritis (CAG), Helicobacter pylori (H. pylori) infection rate and intestinal flora in males aged 40 - 60 with drinking history, providing reference for the treatment of such patients. MethodsA total of 1,500 physical examinees who underwent gastroscopy in the hospital from February 2020 to February 2022 were selected by using cluster sampling method. The prevalence rate of CAG was calculated. According to the prevalence of CAG, the subjects were divided into CAG group (n = 428) and non-CAG group (n = 1,072). The clinical data (including gender, age, drinking history, etc.) of the two groups were analyzed. The prevalence rate of CAG, H. pylori infection rate and intestinal flora in male patients aged 40 - 60 years with drinking history were observed, and the related influencing factors of CAG were analyzed by multivariate Logistic regression analysis. ResultsThere were statistical differences in gender, age, drinking history and H. pylori infection between CAG group and non-CAG group (all P＜0.05). Multivariate Logistic regression analysis showed that age of 40 - 60 years old, male, drinking history and positive H. pylori were independent risk factors for CAG (all P＜0.05). The prevalence rate of CAG in males aged 40 - 60 years with drinking history was 68.68% (296/431), and there were 103 cases (34.80%) with intestinal metaplasia, 83 cases (28.04%) with active inflammation and 45 cases (15.20%) with atypical hyperplasia, and the H. pylori positive rate was 63.51% (188/296). The positive rates of H. pylori in CAG patients with intestinal metaplasia, active inflammation and atypical hyperplasia were higher than those in CAG patients without the above conditions (all P＜0.05). The structures of intestinal flora in CAG males aged 40 - 60 years with drinking history were statistically different from those in non-CAG subjects (all P＜0.05). ConclusionMales aged 40 - 60 years with drinking history have high prevalence rate of CAG, high positive rate of H. pylori infection and serious intestinal flora imbalance. The positive rate of H. pylori is higher in CAG patients with intestinal metaplasia, active inflammation and atypical hyperplasia. Age of 40 - 60 years old, male, drinking history and positive H. pylori infection are independent risk factors for the prevalence of CAG.