Clinical implications of activated leukocyte cell adhesion molecule expression in breast cancer |
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Authors: | Daxun Piao Tao Jiang Gavin Liu Baosheng Wang Jin Xu Anlong Zhu |
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Institution: | (1) Department of General Surgery, The First Clinical Hospital of Harbin Medical University, Harbin, 150001, China;(2) Department of Hepatic-Biliary-Pancreas Surgery, Affiliated ShengJing Hospital, China Medical University, Shenyang, 110004, China; |
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Abstract: | In the study, we enrolled 150 breast cancer cases to investigate the expression status of activated leukocyte cell adhesion
molecule (ALCAM), and the relationships between ALCAM expression and clinical-pathological characteristics and prognosis of
breast cancer. It was observed that ALCAM was expressed at higher levels in breast cancer tissue compared to levels observed
for tumor-adjacent tissue. Compared to cancers with low membranous ALCAM expression, cancers with high membranous ALCAM expression
were prone to lymph node metastasis (χ2 = 15.910, P = 0.010) and metastasis in general (χ2 = 5.211, P = 0.029). High cytoplasmic ALCAM expression was noticeably correlated with local recurrence (χ2 = 7.379, P = 0.012), especially for short-term recurrence (interval <2 years) (χ2 = 5.562, P = 0.037), while not associated to long-term local recurrence (interval >2 years). The content of ALCAM protein is closely
associated with the expression of estrogen receptor (ER) (P = 0.024). The disease-free survival of patients with high cytoplasmic ALCAM expression was significantly shorter compared
to the cases with low cytoplasmic ALCAM expression (P = 0.036). In conclusion, ALCAM expressed at high levels in breast cancer. High membranous expression of ALCAM probably resulted in weakened adherent
ability and metastasis. In addition, high cytoplasmic ALCAM expression strengthened invasive ability of malignant cells and
then promoted tumor development. |
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