The role of functional single nucleotide polymorphisms of the human glucocorticoid receptor gene NR3C1 in Polish patients with bronchial asthma |
| |
| Authors: | Michał Panek Tadeusz Pietras Adam Antczak Paweł Górski Piotr Kuna Janusz Szemraj |
| |
| Institution: | (1) Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland;(2) Department of Pneumology and Allergology, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland;(3) Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland |
| |
| Abstract: | N363S and ER22/23EK polymorphisms observed within glucocorticoid receptor gene (NR3C1) may play an important role in the development
of bronchial asthma. NR3C1 gene is associated with an altered sensitivity to GCs. The aim of the research project was to study
the correlation between this NR3C1 gene polymorphisms and occurrence of asthma in the population of Polish asthmatics. Peripheral
blood was obtained from 207 healthy volunteers and 221 asthma patients. Genotyping was carried out with PCR-RFLP method. In
the groups of patients with uncontrolled moderate asthma and uncontrolled severe disease, the genotype distribution for the
investigated polymorphisms was as follows: N363S-AA, AG, GG occurring with 0.881/0.073/0.046 frequency and ER22/23EK-GG, GA,
AA occurring with 0.963/0.037/0.000 frequency. Chi-square analysis revealed a significantly different (P < 0.05) distribution between cases and controls for the N363S polymorphisms. The N363S polymorphism of NR3C1 gene is significantly
associated with bronchial asthma, susceptibility to the development of moderate to severe form of uncontrolled bronchial asthma. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
