Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus |
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Authors: | Piotr Piotrowski Margarita Lianeri Marzena Olesińska Pawe? P Jagodziński |
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Institution: | (1) Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Święcickiego St, 60-781 Poznań, Poland;(2) Institute of Rheumatology, Warsaw, Poland; |
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Abstract: | Multiple studies have indicated that SLE incidence exhibits a strong genetic background. We studied the frequency of the natural killer group 2, member D (NKG2D) receptor Thr72Ala (rs2255336) polymorphism in patients with SLE (n = 243) and controls (n = 502) in a sample of the Polish population. The p value for SLE patients with the Thr/Thr genotype was 0.0455 and Odds Ratio
(OR) = 0.3846 (95% CI = 0.1458–1.014). For the Thr/Thr and Ala/Thr genotypes we found p = 0.0135 and OR = 0.6556 (95% CI = 0.4684–0.9177).
The frequency of the NKG2D 72Thr allele in patients and controls was respectively, 15 and 21%, P = 0.0046, OR = 0.6547 (95% CI = 0.4877–0.8789). Our studies may confirm that the NKG2D 72Thr gene variant may protect against the incidence of SLE. |
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