Association of interleukin 4 VNTR polymorphism and HIV/AIDS in a north Indian seropositive patients |
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Authors: | Ranbiden Chandera Sobti Nega Berhane Salih Abdul Mahdi Hitnder Takur Ajay Wanch |
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Institution: | (1) Department of Biotechnology, Panjab University, Chandigarh, 1600014, India;(2) Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;(3) Department of Biotechnology, University of Gondar, 196 Gondar, Ethiopia; |
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Abstract: | Despite different efforts made to intervene with the deadly nature of HIV/AIDS, all attempts remained unsuccessful due to
complexity of the viral host interactions. The solution to HIV-1 pandemic is still to come, thus to assist the efforts being
made to intervene with the deadly nature of the virus, different factors responsible for the disease burdens have to be looked
into a systematic manner. As a result, the present study aimed to find out the association of IL-4 VNTR polymorphism with HIV-1 susceptibility and rate of disease progression. Three hundred cases and an equal number of sex
and age matched controls were included for this study. The polymerase chain reaction assay was utilized to genotype IL-4 VNTR. The results of this study showed statistically significant variation among cases and controls in the distribution of
the Rp2/Rp2 genotype (OR = 0.36, 95% CI = 0.18–0.69; P value = 0.0014) indicating, thereby, a possibility of reduced risk of HIV-1 susceptibility. Thus, Rp2/Rp2 genotype of the IL-4 might have a role to play in reducing risk of HIV-1 susceptibility among a north Indian population. |
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