Immunochemical characterization of polysaccharide antigens from six clinical strains of Enterococci |
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| Authors: | Carolyn T Hsu Amanda L Ganong Barbara Reinap Zafiria Mourelatos Johannes Huebner Julia Y Wang |
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| Institution: | (1) Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, MA02115 Boston, USA;(2) Division of Infectious Diseases, Department of Medicine, University Hospital Freiburg, Germany |
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| Abstract: | Background Enterococci have become major nosocomial pathogens due to their intrinsic and acquired resistance to a broad spectrum of antibiotics.
Their increasing drug resistance prompts us to search for prominent antigens to develop vaccines against enterococci. Given
the success of polysaccharide-based vaccines against various bacterial pathogens, we isolated and characterized the immunochemical
properties of polysaccharide antigens from five strains of Enterococcus faecalis and one strain of vancomycin-resistant E. faecium. |
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