A prospective, randomised, controlled clinical study on the assessment of tolerability and of clinical efficacy of Merional (hMG-IBSA) administered subcutaneously versus Merional administered intramuscularly in women undergoing multifollicular ovarian stimulation in an ART programme (IVF) |
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| Authors: | Carlo Alviggi Alberto Revelli Paola Anserini Antonio Ranieri Luigi Fedele Ida Strina Marco Massobrio Nicola Ragni Giuseppe De Placido |
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| Affiliation: | (1) Department of Obstetrica/Gynecological Sciences and Reproductive Medicine, Federico II University, Napoli, Italy;(2) Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, University of Torino, S. Anna Hospital, Torino, Italy;(3) Reproductive Medicine Unit, S. Martino Hospital, Genova, Italy;(4) Reproductive Medicine Unit, S. Paolo Hospital, Milano, Italy |
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| Abstract: | Background Multifollicular ovarian stimulation (MOS) is widely used in IVF and the compliance to treatment is deeply influenced by the tolerability of the medication(s) used and by the ease of self-administration. This prospective, controlled, randomised, parallel group open label, multicenter, phase III, equivalence study has been aimed to compare the clinical effectiveness (in terms of oocytes obtained) and tolerability of subcutaneous (s.c.) self-administered versus classical intramuscular (i.m.) injections of Merional, a new highly-purified hMG preparation. |
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