EFFECT OF BRAIN CORTEX PHOSPHOLIPIDS ON ADENYLATE-CYCLASE ACTIVITY OF MOUSE BRAIN |
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| Authors: | A Leon D Benvegnu G Toffano P Orlando P Massari |
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| Institution: | Fidia Research Laboratories, Abano Terme, Italy and Institute of Pharmacology, University S. Cuore, Roma, Italy |
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| Abstract: | Intravenous injection of a sonicated dispersion of bovine brain phospholipids results in a significant change in both NaF-dependent and dopamine dependent adenylate cyclase activity. High dosage of phospholipids inhibits the dopamine dependent, but not the NaF dependent, adenylate cyclase activity. The stimulation of cyclase activity is accompanied by an increased level of cAMP in mice brains. Treatment with haloperidol abolishes the increase in cAMP. Among individual phospholipids, phosphatidylserine is the most active component for inducing the activation of DA-dependent adenylate cyclase activity. |
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