FIC1, a P-type ATPase linked to cholestatic liver disease,has homologues (ATP8B2 and ATP8B3) expressed throughout the body |
| |
Authors: | Matthew J Harris Irwin M Arias |
| |
Affiliation: | Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA |
| |
Abstract: | ATP8B1/FIC1 is a member of the Type IV P-type ATPase family, which function as ATP dependent aminophospholipid translocases (APLT). We identified two familial intrahepatic cholestasis type 1 (FIC1) homologues, ATP8B2 and ATP8B3, with 53% and 45% amino acid identity, respectively. The expression profile for each gene was determined using a 73-tissue human RNA expression array. The subfamily of FIC1-like proteins is expressed in a wide range of tissues. Given that mutations in FIC1 result in liver disease, these proteins may have important roles in other organs in which they are candidates for genetic and acquired diseases. |
| |
Keywords: | Aminophospholipid translocase PFIC1 BRIC Phospholipid Expression array FIC1 familial intrahepatic cholestasis type 1 BRIC benign recurrent intrahepatic cholestasis APLT aminophospholipid translocase EST expressed sequence tag |
本文献已被 ScienceDirect 等数据库收录! |
|