Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs |
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| Authors: | S Sumi K Inoue R Hosotani M Kogire R Doi M Yun S Higashide H Minote K Takaori H Kaji |
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| Affiliation: | First Department of Surgery, Faculty of Medicine, Kyoto University, Japan. |
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| Abstract: | The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4% at 1 microgram/kg) and the superior mesenteric artery (49.0 +/- 16.8% at 1 microgram/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4 +/- 1.2% at 1 microgram/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow. |
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