Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora |
| |
| Authors: | Lin-Yang Cheng Chun-Lin Chen Yueh-Hsiung Kuo Tsung-Hsien Chang I-Wei Lin Shih-Wei Wang Mei-Ing Chung Jih-Jung Chen |
| |
| Affiliation: | 1. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;2. Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan;4. Department of Biotechnology, Asia University, Taichung 413, Taiwan;5. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan;6. Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan;g. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan;h. Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan |
| |
| Abstract: | A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Garcinia multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1–3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate cancer cell line PC-3 with GI50 values of 4.3?±?1.6 and 6.6?±?0.4?μM, respectively. |
| |
| Keywords: | Guttiferae Polyprenylated polycyclic acylphloroglucinol Garcimultiflorone K Angiogenesis inhibitor |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
