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Kakeromamide A,a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii |
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| Authors: | Fumiaki Nakamura Hiroshi Maejima Midori Kawamura Daisuke Arai Tatsufumi Okino Meng Zhao Tao Ye Jungyeol Lee Young-Tae Chang Nobuhiro Fusetani Yoichi Nakao |
| Institution: | 1. Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;2. Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;3. Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan;4. State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China;5. Department of Chemistry, POSTECH, Pohang 37673, Republic of Korea;6. Fisheries and Oceans Hakodate, 3-1-1 Minato-cho, Hakodate 041-8611, Japan |
| Abstract: | Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey’s method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10?µM. |
| Keywords: | Pentapeptide Cyanobacterium Astrocyte differentiation Neural stem cells Marine natural products |
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