Antiplasmodial flavanones and a stilbene from Carpha glomerata |
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| Authors: | Namki Cho Ana Lisa Valenciano Yongle Du Jason Clement Maria B Cassera Michael Goetz David GI Kingston |
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| Institution: | 1. Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States;2. College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea;3. Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, United States;4. Natural Products Discovery Institute, 2805 Old Easton Road, Doylestown, PA 18902, United States |
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| Abstract: | Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4 (carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3″-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which have prenyl or hydroxyprenyl side chains, exhibited antiplasmodial activities with IC50 values of 5.2?±?0.6, 3.4?±?0.4, and 6.7?±?0.8?µM against the drug-resistant Dd2 strain of Plasmodium falciparum. In addition the prenylated stilbene 5 also showed good activity, with IC50 5.8?±?0.7?µM. |
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| Keywords: | BGEGUEBVMMQCCD-SFHVURJKSA-N XHAKQEHZYZWRLL-KRWDZBQOSA-N PKQKRLPQTWWLMY-AWEZNQCLSA-N IYLCCOVXUHFVHP-AWEZNQCLSA-N ACUJOEGBHPPBCF-AATRIKPKSA-N Cyperaceae Bioassay-guided discovery Antiplasmodial activity |
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