Monodisperse oligoethylene glycols modified Propofol prodrugs |
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| Authors: | Tao Deng Xianglan Mao Yu Li Shaowei Bo Zhigang Yang Zhong-Xing Jiang |
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| Affiliation: | Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China |
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| Abstract: | The low water solubility of Propofol resulted in complicated formulation and adverse effects during its clinical application. To improve its water solubility and maintain its anesthetic effects, Propofol prodrugs with monodisperse oligoethylene glycols as solubility enhancer were designed and synthesized. Monodisperse oligoethylene glycols enable the concise manipulation of water solubility, biocompatibility and anesthetic effects. Through the physicochemical and biological assay, a few water soluble prodrugs of Propofol were identified as promising anesthetic to overcome the drawbacks associated with Propofol. |
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| Keywords: | Propofol Prodrug Polyethylene glycols Anesthetic Monodisperse |
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