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Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2′-deoxyuridine for hepatocellular carcinoma |
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| Authors: | Lorena Rico Michael E Østergaard Melanie Bell Punit P Seth Stephen Hanessian |
| Institution: | 1. Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada;2. Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA;3. Department of Antisense Drug Discovery, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA |
| Abstract: | The anticancer nucleoside 5-fluoro 2′-deoxyuridine-5′-phosphate (5-FdU-P) was attached via an amide chain linker to a triantennary GalNAc cluster as a means to deliver the drug to hepatic cells that recognize the amino sugar units. |
| Keywords: | Liver cancer Drug delivery Nucleoside GalNAc cluster Phosphoramidite |
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