2. Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom
Abstract:
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Highlights? Highlights of recent methods for enhancing natural product yields, activating cryptic clusters, and biosynthetic engineering of natural products. ? Advances in genomics have allowed identification of numerous cryptic biosynthetic clusters. ? Exploitation of regulatory pathways has led to cryptic cluster activation and increased natural product titres. ? Combinatorial biosynthesis, mutasynthesis and protein engineering have led to new derivatives of natural products with modulated biological activity.
