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A retrosynthetic biology approach to therapeutics: from conception to delivery
Authors:Anne-Gaëlle Planson  Pablo Carbonell  Ioana Grigoras  Jean-Loup Faulon
Affiliation:1. Laboratoire de chimie des substances naturelles–EA 1069, faculté de pharmacie, 2, rue du Docteur-Marcland, 87025 Limoges cedex, France;2. Service commun de recherche et d’analyse de biomolécules de Limoges, facultés de médecine et de pharmacie, 2, rue du Docteur-Marcland, 87025 Limoges cedex, France;1. Department of Chemistry, Memorial University of Newfoundland, St. John’s, NL A1B 3X7, Canada;2. Department of Chemistry, Cape Breton University, Sydney, NS B1P 6L2, Canada;3. Department of Chemistry, University of Winnipeg, Winnipeg, MB R3B 2G3, Canada;4. Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada;1. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California
Abstract:
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  • Highlights? Retrosynthetic biology has the potential to identify de novo circuits for therapeutics. ? Retrosynthetic biology performs a metabolic backward search to devise and optimize pathways. ? Production, sensing, and delivery circuits are essential parts of next-generation therapeutics.
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