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A three-state model of telomere control over human proliferative boundaries

Authors:	Anthony J Cesare Jan Karlseder

Institution:	1. Telomere and Genome Stability Group, The Cancer Research UK/Medical Research Council, Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK;2. Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Abstract:	Download : Download high-res image (241KB) Download : Download full-size image Highlights? Human telomeres are protected from the DDR by a higher-order structure. ? Intermediate-state telomeres are susceptible to a DDR and regulate senescence. ? Uncapped-state telomeres are susceptible to fusions and induce crisis. ? Intermediate-state telomeres regulate the prolonged mitosis checkpoint. ? Telomeres may serve as epigenetic sensors of cellular stress.

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