Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women |
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| Authors: | Ying Wang Meng Yang Sang-Gil Lee Catherine G Davis Anne Kenny Sung I Koo Ock K Chun |
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| Institution: | 1. Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA;2. School of Medicine, University of Connecticut Health Center, Farmington, CT, USA;1. Department of Nutrition, Emory University, Atlanta, GA, USA;2. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA;3. Department of Epidemiology, Emory University, Atlanta, GA, USA;4. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA;5. Winship Cancer Institute, Emory University, Atlanta, GA, USA;1. School of Public Health, Xi''an Jiaotong University College of Medicine, 76 Yanta West Road, Xi''an, Shaanxi 710061, China;2. The First Affiliated Hospital, Xi''an Jiaotong University College of Medicine, 277 Yanta West Road, Xi''an, Shaanxi 710061, China;1. Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;2. Department of Pediatrics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;3. Department of Obstetrics and Gynecology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;4. Department of Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;5. Center for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada;6. Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA;1. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS), Italy;2. Nuovo Ospedale Civile di Sassuolo, Sassuolo, Italy;3. EPICOMED Research, srl, Campobasso, Italy;4. Department of Cardiovascular Disease, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Campobasso, Italy;5. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;6. Functional Food and Metabolic Stress Prevention Laboratory, Agricultural Research Center, CRA-NUT, Rome, Italy;7. Department of Food Science, University of Parma, Parma, Italy;1. Tsudaka-Fruit Juice Laboratory, Okayama Research Park Incubation Center, 5303 Haga, Kita-ku, Okayama 701-1221, Japan;2. Department of Life Science, Okayama University of Science, Okayama 700-0005, Japan;3. Kake Medical Science Education Center, Okayama University of Science, Japan;4. Department of Biochemistry, Okayama University of Science, Japan |
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| Abstract: | Increased plasma total antioxidant capacity (TAC) has been associated with a high consumption of fruits and vegetables. However, limited information is available on whether plasma TAC reflects the dietary intake of antioxidants and the levels of individual antioxidants in plasma. By using three different assays, the study aimed to determine if plasma TAC can effectively predict dietary intake of antioxidants and plasma antioxidant status. Forty overweight and apparently healthy postmenopausal women were recruited. Seven-day food records and 12-h fasting blood samples were collected for dietary and plasma antioxidant assessments. Plasma TAC was determined by vitamin C equivalent antioxidant capacity (VCEAC), ferric-reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) assays. TAC values determined by VCEAC were highly correlated with FRAP (r=0.79, P<.01) and moderately correlated with ORAC (r=0.34, P<.05). Pearson correlation analyses showed that plasma TAC values by VCEAC and ORAC had positive correlation with plasma uric acid (r=0.56 for VCEAC; r=0.49 for ORAC) and total phenolics (r=0.63 for VCEAC; r=0.36 for ORAC). However, TAC measured by FRAP was correlated only with uric acid (r=0.69). After multivariate adjustment, plasma TAC determined by VCEAC was positively associated with dietary intakes of γ-tocopherol (P<.001), β-carotene (P<.05), anthocyanidins (P<.05), flavones (P<.05), proanthocyanidins (P<.01) and TAC (P<.05), as well as with plasma total phenolics (P<.05), α-tocopherol (P<.001), β-cryptoxanthin (P<.05) and uric acid (P<.05). The findings indicate that plasma TAC measured by VCEAC reflects both dietary and plasma antioxidants and represents more closely the plasma antioxidant levels than ORAC and FRAP. |
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