Epidemiological,Clinical and Antiretroviral Susceptibility Characterization of Human Immunodeficiency Virus Subtypes B and Non-B in Pernambuco,Northeast Brazil |
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Authors: | Kledoaldo Lima élcio de Souza Leal Ana Maria Salustiano Cavalcanti Daniela Medeiros Salustiano Luzidalva Barbosa de Medeiros Sirleide Pereira da Silva Heloísa Ramos Lacerda |
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Institution: | 1Postgraduate at Department of Tropical Medicine, Federal University of Pernambuco, Recife, Pernambuco, Brazil;2Institute of Biotechnology, Federal University of Pará, Belém, Pará, Brazil;3Sector of Virology, Central Public Health Laboratory of Pernambuco, Recife, Pernambuco, Brazil;4Department of Clinical Medicine, Federal University of Pernambuco, Recife, Pernambuco, Brazil;Fudan University, CHINA |
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Abstract: | BackgroundHIV-1 diversity causes important differences in the virus’ biological properties and their interactions with hosts, such as cell tropism, responses to antiretroviral therapy, drug-resistance, and disease progression.ObjectivesWe evaluated the interrelationship of phylogenetic inference with epidemiological and laboratory data for HIV-1 isolates circulating in Pernambuco, Northeast Region—Brazil.ResultsHIV-1 non-B was associated with female, lower education, lower viral loads, and higher T cell counts mean. Frequencies of co-infection HIV-HBV, HIV-HCV, and HIV-syphilis were 27.8% (95% CI: 19.8–37.7), 1.04% (95% CI: 0.05–5.00) and 14.7% (95% CI: 8.6–23.0), respectively. Drug-resistant mutations rate was 2.98% (95% CI: 1.10–6.47). HIV-HBV subtype B co-infection was associated with men who have sex with men (MSM), higher education, higher viral loads and males. HIV-syphilis subtype non-B co-infection was associated with MSM status, lower T cell counts and males.ConclusionsData showed the importance of molecular characterisations of the HIV-1 epidemic and its relation with epidemiological and clinical characteristics of the population, as well as its association with other infectious diseases, so they can effort to improve preventive measures for health services and more information about the progress and effects of the epidemic in Northeastern–Brazil. |
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