Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats |
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Authors: | S Yamada H I Yamamura W R Roeske |
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Institution: | Departments of Internal Medicine, Pharmacology and Psychiatry, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA |
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Abstract: | The treatment of uninephrectomized rats with deoxycorticosterone (DOCA) and salt for 6 weeks caused a significant systolic hypertension and cardiac and renal hypertrophy. There was a significant decrease in the density of cardiac α1- and β-, and renal α1-adrenoceptors in DOCA/salt hypertensive rats, as compared to uninephrectomized salt loaded control rats. In contrast, the cerebral cortex, corpus striatum, hippocampus and hypothalamus/thalamus of hypertensive rats showed a significant increase in adrenoceptor binding in these hypertensive rats. In contrast, muscarinic cholinergic receptors and 3H]yohimbine binding sites were not altered in most tissues of the hypertensive rats. The present study suggests an important role for central and peripheral α1- and β-adrenoceptors in the pathogenesis of hypertension. |
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Keywords: | Send reprint requests to W R Roeske Dept Int Med U of Az Tucaon Az 85724 |
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