Attenuation of a radiation-induced conditioned taste aversion after the development of ethanol tolerance |
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Authors: | W A Hunt B M Rabin |
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Institution: | Behavioral Sciences Department Armed Forces Radiobiology Research Institute Bethesda, MD 20814-5145. |
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Abstract: | An attempt to reduce a radiation-induced conditioned taste aversion (CTA) was undertaken by rendering animals tolerant to ethanol. Ethanol tolerance, developed over 5 days, was sufficient to block a radiation-induced taste aversion, as well as an ethanol-induced CTA. Several intermittent doses of ethanol, which did not induce tolerance but removed the novelty of the conditioning stimulus, blocked an ethanol-induced CTA but not the radiation-induced CTA. A CTA induced by doses of radiation up to 500 rads was attenuated. These data suggest that radioprotection developing in association with ethanol tolerance is a result of a physiological response to the chronic presence of ethanol not to the ethanol itself. |
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