Expression of Sox1 during Xenopus early embryogenesis |
| |
Authors: | Nitta Kazuhiro R Takahashi Shuji Haramoto Yoshikazu Fukuda Masakazu Onuma Yasuko Asashima Makoto |
| |
Affiliation: | Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. |
| |
Abstract: | Sox B1 group genes, Sox1, Sox2, and Sox3 (Sox1-3), are involved in neurogenesis in various species. Here, we identified the Xenopus homolog of Sox1, and investigated its expression patterns and neural inducing activity. Sox1 was initially expressed in the anterior neural plate of Xenopus embryos, with expression restricted to the brain and optic vesicle by the tailbud stage. Expression subsequently decreased in the eye region by the tadpole stage. Sox1 expression in animal cap explants was induced by inhibition of BMP signaling in the same manner as Sox2, Sox3, and SoxD. In addition, overexpression of Sox1 induced neural markers in ventral ectoderm and in animal caps. These results implicate Xenopus Sox1 in neurogenesis, especially brain and eye development. |
| |
Keywords: | Xenopus laevis Sox1 Sox2 Sox3 Sox B1 SoxD Neural induction |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|