Inhibition of lymphocyte mitogenesis by autoxidized low-density lipoprotein. |
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| Authors: | J Schuh A Novogrodsky R H Haschemeyer |
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| Affiliation: | 1. Department of Biochemistry The New York Hospital-Cornell Medical Center New York, New York 10021 USA;2. Rogosin Kidney Center The New York Hospital-Cornell Medical Center New York, New York 10021 USA |
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| Abstract: | Mitogenic stimulation of lymphocytes is significantly inhibited by addition of human serum low-density lipoprotein that has undergone autoxidation, while no significant effect is seen with non-oxidized lipoprotein. The inhibition is effective for cells stimulated either by the plant lectin phytohemagglutinin or enzymatically by neuraminidase-galactose oxidase treatment. However, it is markedly attenuated when oxidized LDL is added to cells which have been triggered 24 hours earlier. Lipid extracts from oxidized LDL are similarly inhibitory, indicating that the effect is mediated by an oxidized lipid fraction. |
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| Keywords: | LDL low-density lipoprotein PHA phytohemagglutinin NAGO neuraminidase-galactose oxidase TBRS thiobarbituric reactive substances |
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