Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci |
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| Authors: | Marianne Horgan Gary O&#x;Flynn Jennifer Garry Jakki Cooney Aidan Coffey Gerald F Fitzgerald R Paul Ross and Olivia McAuliffe |
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| Institution: | Marianne Horgan, Gary O’Flynn, Jennifer Garry, Jakki Cooney, Aidan Coffey, Gerald F. Fitzgerald, R. Paul Ross, and Olivia McAuliffe |
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| Abstract: | A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells. |
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