Anti-TNF rescue CD4+Foxp3+ regulatory T cells in patients with type 1 diabetes from effects mediated by TNF |
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| Authors: | Ryba Monika Marek Natalia Hak Łukasz Rybarczyk-Kapturska Karolina Myśliwiec Małgorzata Trzonkowski Piotr Myśliwska Jolanta |
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| Affiliation: | 1. Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland;2. Department of Clinical Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland;3. Diabetological Department, Clinic of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdańsk, 80-210 Gdańsk, Poland;1. Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, WA, USA;2. Department of Microbiology, Faculty of Veterinary Medicine, Alexandria University, Egypt;3. Translational Medicine and Research Program, National Marine Mammal Foundation, San Diego, CA, USA;4. U.S Navy Marine Mammal Program, Biosciences Division, Space and Naval Warfare Systems Center Pacific, San Diego, CA, USA;5. Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Pullman, WA, 99164, USA;6. Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, Ames, IA, USA;1. Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea;2. Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Gyeonggi, Korea;3. Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Korea;4. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea;1. Department and Clinic of Reproduction, University of Life Sciences in Lublin, ul. Głęboka 30, 20-612 Lublin, Poland;2. Department of Epizootiology and Clinic of Infections Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-033 Lublin, Poland;3. Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Głęboka 30, 20-612 Lublin, Poland;2. Anesthesiology;3. Biochemistry, Celal Bayar University, School of Medicine, Manisa, Turkey |
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| Abstract: | The presence of low-grade chronic inflammation is a known feature of long standing diabetes type 1. The association between serum level of several markers of inflammation and severity of DM1 was proven. Serum concentrations of TNF were reported to be elevated in diabetic patients, especially those who developed diabetic complications. Lately, it has been also shown that TNF may impair the subset of naturally arising regulatory T cells, which control autoimmunity. The presented study, for the first time, shows the regulatory T cells in the context of an inflammatory environment that is present in patients with type 1 diabetes. It indicates that TNF reduces the number and frequency of regulatory CD4(+)Foxp3(+) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects. |
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