Structure and specific DNA binding of the rat liver glucocorticoid receptor |
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| Authors: | J A Gustafsson J Carlstedt-Duke S Okret A C Wikstr?m O Wrange F Payvar K Yamamoto |
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| Affiliation: | 1. Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital F69, S-14186 Huddinge, Sweden;1. Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, U.S.A.;1. Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA;1. Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA;2. Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA;3. Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;4. Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA;5. Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;6. Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;7. Genome Sciences Facility, Penn State College of Medicine, Hershey, PA, USA |
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| Abstract: | During recent years major advances have been made in our understanding of glucocorticoid mechanism of action. This progress has been made possible by access to purified glucocorticoid receptor in significant amounts as well as by application of hybrid DNA technology within the field of glucocorticoid control of gene expression. Especially the mammary tumour virus genome has turned out to be a convenient experimental system suitable for such investigations. This paper summarizes some of the work carried out in our own laboratory, partially in collaboration with Dr Keith Yamamoto and his associates at the Department of Biochemistry and Biophysics, University of California, San Francisco, U.S.A. |
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