| MTB新疆临床分离株MDR-TB和XDR-TB耐药情况初步调查 |
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| 引用本文： | 曹红艳,吴长东,米利古,刘佩芝,陈伟,王远志,李永祥,袁俐.MTB新疆临床分离株MDR-TB和XDR-TB耐药情况初步调查[J].现代生物医学进展,2010,10(5). |
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| 作者姓名： | 曹红艳 吴长东 米利古 刘佩芝 陈伟 王远志 李永祥 袁俐 |
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| 作者单位： | 1. 石河子大学医学院,新疆,石河子,832002
2. 石河子大学附属第一医院感染科,新疆,石河子,832008 |
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| 基金项目： | 国家自然科学基金资助项目(30960356) |
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| 摘 要： | 目的:分析新疆喀什地区结核分枝杆菌(MTB)临床分离株对4种一线和7种二线抗结核药物的耐药情况,初步探讨本地区耐多药结核病(MDR-TB)和广泛耐药结核病(XDR-TB)的流行情况。方法:收集2008.11.1~2009.10.31日期间新疆喀什地区结核病患者痰液标本,进行分离培养及菌种鉴定,并应用比例法对所分离得到的菌株进行耐药性检测。结果:102株分枝杆菌中,88株(86.3%)属于结核分枝杆菌复合群,7株(6.9%)属于牛型分枝杆菌,7株(6.9%)属于非结核分枝杆菌。对一种以上的抗结核药物具有耐药性的有20株,总耐药率为22.7%(20/88),耐多药率为6.8%(6/88),pre-XDR为33.3%(2/6),无XDR-TB病例。结论:新疆喀什地区结核病患者耐药率较高,在结核病治疗工作中应给予重视,尤其应加强对Pre-XDR的重视,以免发展成XDR-TB。
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| 关 键 词： | 结核分枝杆菌 耐药性 广泛耐药结核 |
Preliminary Investigation on the MDR-TB and XDR-TB of MTB Clinical Isolates From Xinjiang Area |
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| CAO Hong-yan,WU Chang-dong,MI Li-gu,LIU Pei-zhi,CHEN Wei,WANG Yuan-zhi,LI Yong-xiang,YUAN Li.Preliminary Investigation on the MDR-TB and XDR-TB of MTB Clinical Isolates From Xinjiang Area[J].Progress in Modern Biomedicine,2010,10(5). |
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| Authors: | CAO Hong-yan WU Chang-dong MI Li-gu LIU Pei-zhi CHEN Wei WANG Yuan-zhi LI Yong-xiang YUAN Li |
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| Institution: | CAO Hong-yan1,WU Chang-dong1,MI Li-gu1,LIU Pei-zhi2,CHEN Wei1,WANG Yuan-zhi1,LI Yong-xiang1,YUAN Li1 ( 1 College of Medicine,Shihezi University,Xinjiang,832002,China,2 The First Affiliated Hospital of Shihezi University,Department of Infectious Disease,832008,China) |
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| Abstract: | Objective:By drug-susceptibility testing of clinical isolated Mycobacterium tuberculosis (M.TB) to four first-line and seven second-line anti-TB drugs,to know the situation of multidrug resistant tuberculosis(MDR-TB)and extensively drug-resistant tuberculosis (XDR-TB) in part areas of Xinjiang.Methods:The sputum samples of patients with TB were collected from Nov.1th,2008 to Oct.31th,2009 to conduct isolated culture and phenotypical classification.The anti-tuberculosis drugs were performed to detect the dru... |
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| Keywords: | Mycobacterium Tuberculosis Drug-resistant Extensively Drug Resistant Tuberculosis |
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