| 甘氨酸对鲫鱼视网膜ERG b-波和ON型双极细胞活动的调制 |
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| 作者姓名： | Xu XM Yang XL |
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| 作者单位： | 中国科学院上海生理研究所,中国科学院神经生物学开放实验室,上海,200031 |
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| 基金项目： | 国家科委“攀登计划”,上海生命科学中心资助 |
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| 摘 要： | 本工作在分离灌流的鲫鱼视网膜上研究了甘氨酸对明,暗视视网膜电图（ＥＲＧ）ｂ－波和胞内记录的ＯＮ型双极细胞反应的作用。结果表明,甘氨酸能明显压抑ＥＲＧ ｂ－波和ＯＮ型双极细胞的反应,其作用能为士的宁所翻转;甘氨酸对用谷氨酸分离的ＥＲＧ ＰⅢ成分（光感受器电位）无明显影响。这些结果提示,甘氨酸可能直接作用于双极细胞的受体,从而调节视网膜ＯＮ通路的活动。
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| 关 键 词： | 基氨酸 视网膜电图 ON型 双极细胞 调制 |
Glycine modulates the ERG b-waves and ON-type bipolar cells in carp retina |
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| Xu XM,Yang XL.Glycine modulates the ERG b-waves and ON-type bipolar cells in carp retina[J].Acta Physiologica Sinica,1999,0(2):121-127. |
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| Authors: | Xu X M Yang X L |
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| Institution: | Shanghai Institute of Physiology, Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031. |
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| Abstract: | In the present work we investigated the effects of glycine on the electroretinograms (ERG) and light responses of ONtype bipolar cells under dark and lightadapted conditions in superfused, isolated crucian carp retinas. It was revealed that application of 4 mmol/L glycine significantly suppressed the bwaves and the responses of ONtype bipolar cells and the effects were blocked by coapplication of 20 mol/L strychnine. In addition, glycine had no apparent action on the P component (photoreceptor potential) isolated by application of 3 mmol/L glutamate. These results suggest that glycine may act on bipolar cells directly and thus modulate the activity of the ON pathway in the retina. |
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| Keywords: | glycine ERG bwave ONtype bipolar cell modulate glycine receptor |
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