Acetohydroxyacid synthase and its role in the biosynthetic pathway for branched-chain amino acids |
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Authors: | J A McCourt R G Duggleby |
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Institution: | (1) School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia |
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Abstract: | Summary. The branched-chain amino acids are synthesized by plants, fungi and microorganisms, but not by animals. Therefore, the enzymes
of this pathway are potential target sites for the development of antifungal agents, antimicrobials and herbicides. Most research
has focused upon the first enzyme in this biosynthetic pathway, acetohydroxyacid synthase (AHAS) largely because it is the
target site for many commercial herbicides. In this review we provide a brief overview of the important properties of each
enzyme within the pathway and a detailed summary of the most recent AHAS research, against the perspective of work that has
been carried out over the past 50 years. |
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Keywords: | : Acetohydroxyacid synthase – Acetolactate synthase – Branched-chain amino acids – Thiamin diphosphate – Flavin adenine dinucleotide – Herbicide – Inhibitor – Mechanism – Protein structure |
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