| Abstract: | In pregnant females B1-hypovitaminosis was induced by injecting various doses of oxythiamine--a specific antimetabolite for B1 vitamin. The rat and hamster embryos were respectively treated on the 20th and 15th days of development after the technique suggested by Dauson-Dyban with staining the osseous anlages of the skeletons with alizarine red. The results of the investigations performed in 193 skeletons of the rat embryos and in 196 skeletons of the golden hamster embryos revealed a progressive decrease, as the dose of oxythiamine increased, in length of ossification anlages of the extremity bones. However, susceptibility to lesions in various bones of the extremity and skull skeletons was not similar under conditions of progressive oxythiamine-induced B1-hypovitaminosis and depended on time of their anlage formations. |
