Role of endothelial progenitor cells in cancer progression |
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| Authors: | Michele Moschetta Yuji Mishima Ilyas Sahin Salomon Manier Siobhan Glavey Angelo Vacca Aldo M. Roccaro Irene M. Ghobrial |
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| Affiliation: | 1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;2. University of Bari Medical School, Department of Biomedical Sciences and Human Oncology (DIMO), Section of Internal Medicine and Clinical Oncology, Bari, Italy |
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| Abstract: | Tumor-associated neovasculature is a critical therapeutic target; however, despite significant progress made in the clinical efficacy of anti-vessel drugs, the effect of these agents remains transient: over time, most patients develop resistance, which inevitably leads to tumor progression. To develop more effective treatments, it is imperative that we better understand the mechanisms involved in tumor vessel formation, how they participate to the tumor progression and metastasis, and the best way to target them. |
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| Keywords: | Endothelial progenitor cells Cancers Hematological malignancies Vasculogenesis |
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