WWOX at the crossroads of cancer,metabolic syndrome related traits and CNS pathologies |
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Authors: | C Marcelo Aldaz Brent W Ferguson Martin C Abba |
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Institution: | 1. Department of Molecular Carcinogenesis, Science Park, The University of Texas M.D. Anderson Cancer Center, Smithville, TX 78957, USA;2. CINIBA, Facultad de Medicina, Universidad Nacional de La Plata, La Plata, Argentina |
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Abstract: | WWOX was cloned as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. Deletions affecting WWOX accompanied by loss of expression are frequent in various epithelial cancers. Translocations and deletions affecting WWOX are also common in multiple myeloma and are associated with worse prognosis. Metanalysis of gene expression datasets demonstrates that low WWOX expression is significantly associated with shorter relapse-free survival in ovarian and breast cancer patients. Although somatic mutations affecting WWOX are not frequent, analysis of TCGA tumor datasets led to identifying 44 novel mutations in various tumor types. The highest frequencies of mutations were found in head and neck cancers and uterine and gastric adenocarcinomas. |
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Keywords: | WWOX FRA16D TGFβ WNT Lipid metabolism Epilepsy |
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