|
|||||
|
|
Synthesis and biological evaluation of aristolactams |
|
| Authors: | Couture Axel Deniau Eric Grandclaudon Pierre Rybalko-Rosen Hélène Léonce Stéphane Pfeiffer Bruno Renard Pierre |
| Institution: | a Laboratoire de Chimie Organique Physique, ESA CNRS 8009, Bâtiment C3(2), UST Lille, F-59655, Villeneuve d'Ascq Cédex, France b Institut de Recherches Servier, Division de Cancérologie Expérimentale, 11, rue des Moulineaux, F-92150, Suresnes, France c SERVIER, 1, rue Carle Hébert, F-92415, Courbevoie Cédex, France |
| Abstract: | A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |