Induction of micronucleated reticulocytes by potassium bromate and potassium chromate in CD-1 male mice. |
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| Authors: | T Awogi K Murata M Uejima T Kuwahara S Asanami K Shimono T Morita |
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| Affiliation: | Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan. |
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| Abstract: | Micronucleus tests of potassium bromate (KBrO3) and potassium chromate (K2CrO4) were conducted with peripheral blood reticulocytes (PB-RETs) of CD-1 male mice dose intraperitoneally. Peripheral blood cells collected from the tail were stained supravitally with acridine orange (AO) using AO-coated glass slides. Both KBrO3 and K2CrO4 induced micronuclei in PB-RETs in the same manner as in polychromatic erythrocytes of bone marrow. |
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