New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3 |
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| Authors: | Takeda Yasuyuki Yoshino Toshiharu Uoto Kouichi Chiba Jun Ishiyama Takashi Iwahana Michio Jimbo Takeshi Tanaka Noriko Terasawa Hirofumi Soga Tsunehiko |
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| Institution: | Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo R&D Center, 16-13 Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. |
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| Abstract: | We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration. |
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