Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide |
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Authors: | J K Wiencke W F Morgan |
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Institution: | 1. Utsunomiya University, Utsunomiya 321-8585, Japan;2. Laboratoire de Physique des Gaz et des Plasmas (LPGP), Université Paris-Saclay, France;3. Institute of Physics of the ASCR, ELI-Beamlines, Na Slovance 2, Prague 18221, Czech Republic;4. Institute of Plasma Physics of the CAS, Za Slovankou 1782/3, Prague 18200, Czech Republic |
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Abstract: | The poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide had dramatically different effects on X-ray-induced cytogenetic damage in human lymphocytes depending on the stage of the cell cycle in which cells were irradiated. 3-Aminobenzamide (0.08-3.00 mM) potentiated the frequency of chromosomal aberrations when lymphocytes were irradiated in G1, S, or late G2. No effect was observed, however, when lymphocytes were irradiated in G0 or at the S/G2 boundary 6 h before termination of culture. These results indicate that poly(ADP-ribose) polymerase may be involved in chromosomal repair of radiation damage only during specific stages of the cell cycle. |
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