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A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis |
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| Authors: | Yuzuru Mikami Sen Feng Yu Katsukiyo Yazawa Kazutaka Fukushima Akio Maeda Jun Uno Kiyoshi Terao Naoki Saito Akinori Kubo Ken -ichiro Suzuki |
| Affiliation: | (1) Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, 280 Chiba City, Japan;(2) Department of Organic Chemistry, Meiji College of Pharmacy, 1-35-23, Setagaya-ku, Tokyo, Japan;(3) Japan Collection of Microorganisms, RIKEN, 351-01, Wako-shi, Saitama, Japan |
| Abstract: | During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans. |
| Keywords: | Nocardia otitidiscaviarum cutaneous nocardiosis toxic substance chemical structure |
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