Studies on the in vitro effects of bithionol and menichlopholan on flukes of Clonorchis sinensis, Metagonimus takahashii and Paragonimus miyazakii. |
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| Authors: | F Hamajima T Fujino K Yamagami N Eriguchi |
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| Institution: | 1. Department of Parasitology, National Defense Medical College, Tokorozawa 359, Japan;2. Department of Parasitology, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan |
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| Abstract: | The present study was carried out in order to obtain information on the action of bithionol and menichlopholan on Clonorchis sinensis, Metagonimus takahashii and Paragonimus miyazakii. The drugs inhibited the motility of the newly excysted juveniles and adult worms in vitro. Moreover, the in vitro treatment slightly decreased lactate dehydrogenase activity in homogenates of adult worms. The drug treatments of adult worms in vitro also inhibited the activity of fumarate reductase, malic enzyme, phosphogluconate dehydrogenase and succinate dehydrogenase in the homogenate. In addition to this, these drugs caused morphological alterations in the ultrastructure of the tegument of the flukes. |
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| Keywords: | Clonorchis sinensis Metagonimus takahashii Paragonimus miyazakii bithionol menichlopholan flukes newly excysted juveniles adult worms motility homogenate enzymes lactate dehydrogenase fumarate reductase malic enzyme phosphogluconate dehydrogenase succinate dehydrogenase inhibition ultrastructure tegument |
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