Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9 |
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Authors: | Srinivasan Periasamy Dur-Zong Hsu Shin-Yi Chen Shan-Shan Yang Victor Raj Mohan Chandrasekaran Ming-Yie Liu |
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Institution: | (1) Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan, 70428, Taiwan;(2) Research Center for Environmental and Occupational Health and Preventive Medicine, National Cheng Kung University Medical College, Tainan, 70428, Taiwan; |
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Abstract: | We investigated the therapeutic effect of sesamol against monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats.
Male Sprague–Dawley rats were gavaged with a single dose of monocrotaline (90 mg/kg) to induce SOS. Sesamol (5, 10, 20, and
40 mg/kg) was subcutaneously injected 24 h after monocrotaline treatment. Control rats were given saline only. Aspartate transaminase,
alanine transaminase, mast cells, CD 68+ Kupffer cells, neutrophils, myeloperoxidase, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1
(TIMP-1), laminin, and collagen were assessed 48 h after monocrotaline treatment. All tested parameters, except for TIMP-1,
laminin, and collagen, were significantly higher in monocrotaline-treated rats than in control rats, and, except for TIMP-1,
laminin, and collagen, significantly lower in sesamol-treated rats than in monocrotaline-treated rats. In addition, liver
pathology revealed that sesamol offered significant protection against SOS. We conclude that a single dose of sesamol therapeutically
attenuated SOS by decreasing the recruitment of inflammatory cells, downregulating MMP-9, and upregulating TIMP-1 expression. |
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