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Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study |
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| Authors: | Minoru Satoh Malgorzata E Krzyszczak Yi Li Angela Ceribelli Steven J Ross Edward KL Chan Mark S Segal Michael R Bubb Eric S Sobel Westley H Reeves |
| Institution: | (1) Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA;(2) Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA;(3) Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA;(4) Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA |
| Abstract: | IntroductionThe presence of anti-topoisomerase I (topo I) antibodies is a classic scleroderma (SSc) marker presumably associated with a unique clinical subset. Here the clinical association of anti-topo I was reevaluated in unselected patients seen in a rheumatology clinic setting. |
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