Telomere biology of trypanosomatids: beginning to answer some questions |
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| Authors: | Lira Cristina B B Giardini Miriam A Neto Jair L Siqueira Conte Fábio F Cano Maria Isabel N |
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| Institution: | 1. Laboratório de Telômeros, Departamento de Genética, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu, SP, Brazil;2. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil;3. Departamento de Genética Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil;1. Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil;2. Instituto Carlos Chagas/Fiocruz-PR, Curitiba, PR, Brazil;1. Molecular and Translational Cardiology, Department of Cardiovascular Medicine, University Hospital Münster, Germany;2. Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic;1. Department of Organismal Biology and Anatomy, The University of Chicago, USA;2. Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, USA;3. The College, The University of Chicago, USA;4. Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, USA;5. Department of Basic Science, Touro University California, USA;1. Seattle Biomedical Research Institute, 307 Westlake Avenue N., Seattle WA 98109-5219, USA;2. Department of Biomedical Informatics & Medical Education, Seattle, WA 98195, USA;3. Department of Global Health, University of Washington, Seattle, WA 98195, USA;1. Dipartimento di Fisica and CNISM, Sapienza Università di Roma, Piazzale A. Moro 5, I-00185 Roma, Italy;2. CNIS – SAPIENZA Università di Roma, Italy;3. CNR-IPCF UOS Roma, Italy |
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| Abstract: | Studies of telomere structure and maintenance in trypanosomatids have provided insights into the evolutionary origin and conservation of some telomeric components shared by trypanosomes and vertebrates. For example, trypanosomatid telomeres are maintained by telomerase and consist of the canonical TTAGGG repeats, which in Trypanosoma brucei can form telomeric loops (t-loops). However, the telomeric chromatin of trypanosomatids is composed of organism-specific proteins and other proteins that share little sequence similarity with their vertebrate counterparts. Because telomere maintenance mechanisms are essential for genome stability, we propose that the particular features shown by the trypanosome telomeric chromatin hold the key for the design of antiparasitic drugs. |
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