Adoptive transfer of tsk skin fibrosis to +/+ recipients by tsk bone marrow and spleen cells |
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Authors: | M A Walker R A Harley F A DeLustro E C LeRoy |
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Institution: | Department of Medicine, Medical University of South Carolina, Charleston 29425. |
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Abstract: | The tight skin mouse (Tsk/+) is an autosomal dominant example of inherited fibrosis whose pathogenesis is unclear. Autoimmune phenomena have been described previously. This study demonstrates the adoptive transfer of skin fibrosis to lethally irradiated syngeneic +/+ recipients by the transplantation of both bone marrow and spleen cells. The recipient skin fibrosis was not associated with mast cell proliferation or degranulation as it is in the tsk/+ mouse, representing for the first time a dissociation between mast cells and fibrosis and introducing the potential for direct T cell-fibroblast interactions. |
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