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Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway
Authors:Shin-Kang Sonyo  Ramsauer Victoria P  Lightner Janet  Chakraborty Kanishka  Stone William  Campbell Sharon  Reddy Shrikanth A G  Krishnan Koyamangalath
Affiliation:
  • a Division of Hematology-Oncology, Department of Internal Medicine, JamesH. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
  • b Department of Pharmaceutical Sciences , Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA
  • c Department of Pediatrics, James H. Quillen College of Medicine, Tennessee State University, Johnson City, TN 37614, USA
  • d Department of Biochemistry, James H. Quillen College of Medicine and Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA
  • e Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • Abstract:
    Keywords:Tocotrienols   Vitamin E   Pancreatic cancer   AKT   ERK   Free radicals
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