2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways

Authors:	Kachadourian Remy Pugazhenthi Subbiah Velmurugan Kalpana Backos Donald S Franklin Christopher C McCord Joe M Day Brian J

Institution:	^a Department of Medicine, National Jewish Health, Denver, CO 80206, USA ^b Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA ^c Denver VA Medical Center, Denver, CO 80220, USA ^d Department of Pharmaceutical Sciences, University of Colorado at Denver, Aurora, CO 80045, USA

Abstract:

Keywords:	AP-1 activator protein-1 ARE antioxidant-response element BCRP breast cancer resistance protein BSO l-buthionine sulfoximine" target="_blank">l-buthionine sulfoximine 2&prime 5&prime -DHC 2&prime 5&prime -dihydroxychalcone ERK extracellular-signal-regulated kinase GCLC glutamate-cysteine ligase catalytic subunit GCLM glutamate-cysteine ligase regulatory subunit GSH reduced glutathione HO-1 heme oxygenase-1 2&prime -HC 2&prime -hydroxychalcone HC hydroxychalcone JNK c-Jun N-terminal kinase LDH lactate dehydrogenase MAPK mitogen-activated protein kinase MnTDE-1 3-IP⁵⁺ manganese(III) meso-tetrakis(N N&prime -diethylimidazolium-2-yl)porphyrin MRP multidrug resistance-associated protein NAC N-acetylcysteine PI3K phosphatidylinositol 3-kinase ROS reactive oxygen species Nrf2 NF-E2-related factor-2
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