Coenzyme Q and vitamin E need each other as antioxidants |
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Authors: | V E Kagan J P Fabisiak P J Quinn |
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Institution: | (1) Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, 260 Kappa Drive, RIDC Park, 15238 Pittsburgh, PA, USA;(2) Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania;(3) Department of Biochemistry, King’s College London, London |
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Abstract: | Summary Both vitamin E and coenzyme Q possess distinct lipoprotective antioxidant properties in biological membranes. Their combined
antioxidant activity, however, is markedly synergistic when both are present together. While it is likely that vitamin E represents
the initial chain-breaking antioxidant during lipid peroxidation, both fully reduced CoQH2 (ubiquinol) and semireduced CoQH. (ubisemiquinone) appear to efficiently recycle the resultant vitamin E phenoxyl radical back to its biologically active reduced
form. We describe and support a potential kinetic mechanism whereby vitamin E and coenzyme Q interact in such a way as to
usurp the prooxidant effects of O
2
−.
. Physical interactions of vitamin E and coenzyme Q within the environment of the membrane lipid bilayer facilitate the recycling
of vitamin E by ubisemiquinone and ubiquinol. Lastly, data are linked into a catalytic cycle that serves to connect normal
electron transport mechanisms within biological membranes to the maintenance of lipoprotective antioxidant mechanisms. |
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Keywords: | Vitamin E Coenzyme Q Electron transport Antioxidant Lipid peroxidation Superoxide |
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