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Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor |
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| Authors: | Jorma A Määttä Kaisa Olli Tiina Henttinen Minna T Tuittila Klaus Elenius Markku Salmivirta |
| Affiliation: | 1. Turku Center for Disease Modeling/Department of Cell Biology and Anatomy, University of Turku, Turku, Finland 2. Turku Centre for Biotechnology, University of Turku and ?bo Akademi University, Turku, Finland 3. Department of Medical Biochemistry and Molecular Biology and Medicity Research Laboratory, University of Turku, Turku, Finland |
| Abstract: | BackgroundNuclear localization of proteolytically formed intracellular fragment of ErbB4 receptor tyrosine kinase has been shown to promote cell survival, and nuclear localization of ErbB4 receptor has been described in human breast cancer. Tumor necrosis factor alpha converting enzyme (TACE) initiates the proteolytic cascade leading to ErbB4 intracellular domain formation. Interactions between matrix metalloproteases and heparan sulfate have been described, but the effect of cell surface heparan sulfate on TACE activity has not been previously described. |
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