盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎的临床研究

目的:研究盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎的临床价值。方法:选取2011年1月至2014年2月已被收治的符合标准的病例共150例,按照病情轻重分为轻度(64例)、中度(52例)及重度(34例)3组,各组又随机等分为治疗组和对照组两组,治疗组给盐酸氨基葡萄糖联合塞来昔布治疗,对照组仅给予盐酸氨基葡萄糖治疗,分别于给药第2、4、6周以及停药8、12周观察两组患者经两种不同的治疗方案治疗后患者的Lequesne评分有无统计学差异。结果:轻度:两组停药12周后Lequesne评分仍低于治疗前,差异有统计学意义(P0.05),停药12周时治疗组低于对照组,差异有统计学意义(P0.05)。中度:用药2周、4周、6周及停药8周时两组相比差异均有统计学意义(P0.05)。重度:对照组与治疗组在给药4周及给药6周时其Lequesne评分差异有统计学意义(P0.05),停药后均无统计学意义(P0.05)。结论:单用盐酸氨基葡萄糖可改善轻度膝关节骨性关节炎的临床症状,对于中度患者联合非类固醇类抗炎药类有较好疗效,对于重度患者两种方式都无明显效果。

The Clinical Study of Glucosamine Hydrochloride Combined with Celecoxibfor Different Degrees of Knee Osteoarthriti

Objective:To study the clinical significance of glucosamine hydrochloride combined with celecoxib in the treatment ofdifferent degrees of knee osteoarthriti.Methods:150 cases who were in accordance with the standards in our hospital from January 2012to February 2014 were selected and divided into the mild group, moderate group and severe group according to the severity, and eachgroup was further equally divided into the treatment group and the control group randomly, the treatment group was given glucosaminehydrochloride combined with celecoxib, while the control group was given glucosamine hydrochloride. Lequesne score were recorded at2, 4, 6 weeks after drug administration and 8 and 12 weeks after drug withdrawal, data were compared between the two groups andamong different time points.Results:In the mild group, the lequesne score of the two groups at 1 2 weeks after drug withdrawal werelower than that before the treatment, the difference was statistically significant (P<0.05), the lequesne score in the treatment group waslower than that in the control group in 1 2 weeks after drug withdrawal, the difference was statistically significant (P<0.05); In moderategroup, there were statistically significantly differences in the comparison of the two groups at the time of 2, 4, 6 weeks after drugadministration and 8 weeks after drug withdrawal (P<0.05); In severe group, there were statistically significantly differences incomparison of the two groups at 4 and 6 weeks after drug administration (P<0.05), and there were no statistically significant differencesafter drug withdrawal(P>0.05).Conclusion:Using pure glucosamine hydrochloride could improve the clinical symptoms in patients withmild knee osteoarthriti, glucosamine hydrochloride combined with celecoxib has good curative effects for moderate patients, whileneither of the two treatment methods has obvious effects on severe patients.